This peer-reviewed research published in the British Journal of Pharmacology demonstrates that D-Pinitol significantly reduces tau hyperphosphorylation through a novel mechanism involving the regulation of cyclin-dependent kinase 5 (CDK5). Using multiple in vivo models, including genetic tauopathy (3xTg mice), the study shows that D-Pinitol decreases the activity of CDK5 by reducing its regulatory subunits p25 and p35, leading to effective tau dephosphorylation.
Importantly, the effect occurs independently of the classical GSK-3β pathway and insulin receptor activation, defining a unique and differentiated mechanism of action. These findings position D-Pinitol as a nutraceutical candidate targeting key molecular drivers of tauopathies and neurodegenerative processes associated with metabolic dysfunction and aging.