Gyneos® D-Chiro-Inositol for Women

Overview

D-Chiro-Inositol for women’s health at every life stage — from hormonal balance to healthy brain aging.

Designed for

Brands developing women’s health formulations for every life stage — from early adulthood through menopause and healthy aging. A versatile active for products focused on hormonal balance, metabolic wellness, bone support, and cognitive support in women.

Why It Works

Science-backed, naturally sourced, and well-tolerated. Gyneos® is a standardized, traceable source of D-Chiro-Inositol that may help support healthy hormonal balance, healthy insulin response, and normal cognitive and bone function — built on 30+ years of scientific expertise in clean, solvent-free production.

How to Use

Formulated ffor daily-use products. Gyneos® is fully water-soluble, neutral in taste, and stable across formats, giving formulators flexibility across tablets, sticks, gummies, RTDs, and more.

From carob’s natural D-Pinitol, by a clean biomimetic process

Gyneos® begins with D-Pinitol, a bioactive naturally present in the pods of the carob tree (Ceratonia siliqua). Using a water-based process, we extract and purify the D-Pinitol, then convert it to D-Chiro-Inositol by acid demethylation — the same conversion the human body performs in the stomach. The resulting D-Chiro-Inositol is purified and crystallized to ≥98% final purity. Every stage — extraction, purification, conversion, and crystallization — is free of organic solvents. This is the fundamental distinction from both synthetic D-Chiro-Inositol and conventional extraction methods, which rely on organic solvents at nearly every step, including crystallization.

Discover how Gyneos® can support women’s health — naturally.

Disclaimer:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Appearance:

White to off-white-crystalline powder.

Small molecule:

Small molecule.

Melting range:

ca. 230ºC

Suggested use:

150-600 mg/day

Taste:

Only slightly sweet, no distinct side-or aftertaste.

Assay (USP):

min. 98 %.

Dosage:

Oral.

Bioaviability:

Oral bioavailability demonstrated in preclinical models, with systemic action on insulin signaling. Stable and well-absorbed.

Loss on drying:

max. 2%.

Solubility:

Highly water-soluble, ideal for capsules, powders, and functional beverages.

Stability:

Chemically stable under standard storage conditions, with excellent shelf-life across common formulation formats.

Science-backed support for women's metabolic and hormonal health — and, increasingly, healthy brain aging.

Gyneos® begins with D-Pinitol, a bioactive naturally present in the pods of the carob tree (Ceratonia siliqua). Using a clean, water-based process, we convert it to D-Chiro-Inositol by acid demethylation — the same conversion the human body performs — then purify and crystallize it to ≥98% purity, free of organic solvents at every stage.

Gyneos® delivers ≥98% pure D-Chiro-Inositol, naturally derived from carob D-Pinitol. Fully traceable and free of organic solvents at every stage.

Naturally sourced and fully traceable, with supply-chain control from raw material to finished ingredient.

Ultra-Pure DCI

≥98% purity, with pharma-grade analytical precision.

Fully Water-Soluble

Dissolves easily in any format ;no binders, no grit.

Multi-Target Support

Supports healthy ovulatory function, healthy insulin response, and hormonal balance.

One Simple Dose

Convenient daily support for reproductive, bone, and metabolic wellness

100% natural and traceable
Naturally derived from carob, with full supply-chain control

From carob's natural D-Pinitol.

Gyneos® begins with D-Pinitol, a bioactive naturally present in the pods of the carob tree (Ceratonia siliqua). We convert it to D-Chiro-Inositol by acid demethylation — the same conversion the human body performs in the stomach — using a clean, water-based process free of organic solvents at every stage.

A powerful molecule from a resilient tree

While myo-inositol is widely present in foods and plants, D-Chiro-Inositol is far rarer in nature and plays a distinct role in insulin signaling. Rather than extract it directly, we produce it from the abundant D-Pinitol in carob — mirroring the body's own conversion.

Backed by peer-reviewed science.

Over the last 30 years, preclinical and clinical research has characterized how D-Chiro-Inositol supports healthy ovulatory function, healthy insulin response, and — most recently, in collaboration with Karolinska Institutet — neural insulin signaling relevant to healthy brain aging.

Mechanism of action

Gyneos® acts through multiple, interconnected pathways that span metabolic, hormonal, and cognitive health — from enhancing insulin sensitivity and supporting healthy ovarian function to protecting long-term brain health.

Insulin Signaling and Sensitization

Regulation of ovarian steroidogenesis

Enhancement of glycogen synthesis

Modulation of Lipid Metabolism

Modulation of neuroinflammatory signaling (microglial phenotype)

Modulation of the GSK-3β / CDK5 axis and site-selective tau regulation — brain insulin signaling

Reduction of amyloid burden in preclinical models

Support of neuronal insulin sensitivity and cognitive function

HEALTHY REPRODUCTION

HEALTHY METABOLISM

HEALTHY AGING

Features & Benefits

Clinically Driven Benefits

Gyneos® delivers clinically supported benefits across women's health — from promoting healthy ovulatory function and insulin response to supporting bone strength and cognitive health, through a well-tolerated, non-hormonal mechanism.

Supports healthy ovulatory function

Supports healthy insulin response

Supports bone strength and mineral balance

Non-hormonal mechanism; well-tolerated

Multi-targeted action across systems

Supports cognitive function and healthy brain aging

Formulation Advantages

Gyneos® is formulated for effortless integration — fully water-soluble, neutral in taste, and heat-stable, with pharma-grade purity and dosing flexibility backed by over 30 years of scientific expertise.

Fully water-soluble and easy to blend

Neutral taste, ideal for any format

Heat-stable for manufacturing flexibility

≥98% pure DCI – pharma-grade

Adjustable dosing based on need

Validated with over 30 years of expertise

Ingredients Excellence

Water-soluble

Vegetarian

Vegan

Pesticide free

Non GMO

Naturally sourced

Made in EU

Gluten free

Fully traceable

Free of organic solvents

Proven Health Impact

Reproductive wellness

Hormonal balance

Healthy insulin response

Healthy appetite regulation

Cognitive function & brain aging

Bone support

Trusted Certifications

Kosher

ISO 9001

ISO 22000

ISO 14001

Halal

GMP

Propietary Research

Peer-Reviewed Evidence for Women's Health and Healthy Aging

In preclinical research, Gyneos® was associated with improved ovarian function, embryo development, and implantation, alongside improved glucose tolerance. Source: Pericuesta E, et al. D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome. Int J Mol Sci. 2020 Aug 22;21(17):6049.

In aged mouse models, Gyneos® was associated with improved ovarian and reproductive outcomes

Reproductive benefits documented in preclinical models

Gyneos® supports healthy insulin signaling — the mechanism underlying its metabolic and cognitive research

CLINICAL RESEARCH HIGHLIGHTS:

1. Improves Insulin Sensitivity

DCI supplementation enhances insulin signaling, lowering fasting insulin and improving glucose tolerance in women with PCOS and in patients with insulin resistance or type 2 diabetes.

2. Reduces Hyperandrogenism in PCOS

Clinical trials show DCI reduces circulating testosterone and other androgens, helping to alleviate symptoms like acne, hirsutism, and menstrual irregularities.

3. Restores Ovulation and Fertility

By normalizing insulin response and reducing hyperandrogenism, DCI supports follicular development and ovulation, improving spontaneous pregnancy rates in women with PCOS.

4. Benefits Metabolic Health Beyond PCOS

Evidence points to improved lipid profiles, reduced triglycerides, and lower blood pressure in some cohorts, highlighting potential benefits in metabolic syndrome management .

D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome Pericuesta E, Laguna-Barraza R, Ramos-Ibeas P, Gutierrez-Arroyo JL, Navarro JA, Vera K, Sanjuan C, Baixeras E, de Fonseca FR, Gutierrez-Adan A. Int J Mol Sci. 2020 Aug 22;21(17):6049

Read the full article

nutrients peer review scientific magazine

Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3×Tg Humanized Mouse Model of Alzheimer’s Disease Pacheco-Sánchez B et al_2025_Nutrients.

Read the full article

Dietary administration of D-chiro-inositol attenuates sex-specific metabolicimbalances in the 5xFAD mouse model of Alzheimer’s disease Lopez-Gambero AJ et al_2022_Biomedicine & Pharmacotherapy

Read the full article

biomedicines peer review scientific magazine

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases Lopez-Gambero AJ et al_2020_Biomedicines

Read the full article

Market Opportunities

Women’s health

Supporting vitality, hormonal health, and performance across every life stage. From early adulthood to healthy aging.

Weight and metabolic management

Evidence-driven metabolic and appetite homeostasis

Cognitive performance

Supporting mental clarity, focus, and long-term memory brain function.

Joint & bone

Supporting structural integrity and mineral balance of bones.

Applications

Tablets

Sticks Packs

Soft Gels

RTDS / Shots

Powders

Gummies

Chews

Capsules

Origins

Rooted in the Mediterranean, crafted with purpose.

Gyneos® begins its story in the Mediterranean basin, where the resilient carob tree (Ceratonia siliqua) has flourished for centuries. Its pods are a natural source of D-Pinitol — the precursor we convert to D-Chiro-Inositol through the same biochemical step the human body uses. We combine this ancient crop with modern precision to deliver a clean, plant-derived ingredient for women's health.

Born from science, focused on women.

Our founders have worked with D-Chiro-Inositol since the 1990s, among the first to produce it at industrial scale from carob-derived D-Pinitol. More than 30 years of process development, purification, and analytical refinement stand behind every batch of Gyneos®, produced to ≥98% purity by a clean process free of organic solvents at every stage.

Precision and control, from raw material to finished ingredient.

Our integrated process gives us control and traceability through every step: extraction, purification, conversion, standardization, and in-house analytical testing. This short, transparent flow ensures consistency, safety, and pharmaceutical-grade standards batch after batch.

Total traceability, backed by testing.

We are embedded in the entire process, from raw material to finished ingredient. That integration lets us guarantee traceability and integrity at every stage. Rigorous testing in our certified labs confirms that each batch of Gyneos® delivers stable, clean, consistent D-Chiro-Inositol.

Designed for women's health, grounded in science.

Gyneos® supports women's hormonal and metabolic balance through a non-hormonal mechanism on insulin signaling. One naturally-derived, science-backed ingredient — supporting women's health across life stages, from reproductive years through healthy aging.

Disclaimer:
The information presented in this page is intended to provide general information on our premium products, their properties and potential applications. It is based on our present state of knowledge and must not be construed as guaranteeing specific properties or approvals of the products described herein or their suitability for any application described. The user is solely responsible for compliance with the existing approvals in the county of use. It is also the sole responsibility of the user to investigate whether existing patents are infringed by the use of the materials described herein. Adequate quality of our products is guaranteed under our General Conditions of Sales. All statements in this page have not been evaluated by the US Food and Drug Administration or EFSA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Gyneos

D-Chiro-Inositol for Women’s Metabolic & Hormonal Health Across Life Stages

Overview

D-Chiro-Inositol for women’s health at every life stage — from hormonal balance to healthy brain aging.

Designed for

Why It Works

How to Use

From carob’s natural D-Pinitol, by a clean biomimetic process

Appearance:

Small molecule:

Melting range:

Suggested use:

Taste:

Assay (USP):

Dosage:

Bioaviability:

Loss on drying:

Solubility:

Stability:

Science-backed support for women's metabolic and hormonal health — and, increasingly, healthy brain aging.

Naturally sourced and fully traceable, with supply-chain control from raw material to finished ingredient.

100% natural and traceable Naturally derived from carob, with full supply-chain control

Mechanism of action

HEALTHY REPRODUCTION

HEALTHY METABOLISM

HEALTHY AGING

Features & Benefits

Clinically Driven Benefits

Formulation Advantages

Ingredients Excellence

Proven Health Impact

Trusted Certifications

Propietary Research

Peer-Reviewed Evidence for Women's Health and Healthy Aging

In aged mouse models, Gyneos® was associated with improved ovarian and reproductive outcomes

Reproductive benefits documented in preclinical models

Gyneos® supports healthy insulin signaling — the mechanism underlying its metabolic and cognitive research

CLINICAL RESEARCH HIGHLIGHTS:

1. Improves Insulin Sensitivity

2. Reduces Hyperandrogenism in PCOS

3. Restores Ovulation and Fertility

4. Benefits Metabolic Health Beyond PCOS

Market Opportunities

Applications

Origins

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100% natural and traceable
Naturally derived from carob, with full supply-chain control