Safforce+

Overview

Designed For

Clinically standardized saffron extract (safranal + crocins) with guaranteed active content — quantified by HPLC, not UV-VIS like most competitors.

What Sets Us Apart

Unlike conventional saffron extracts with uncertain actives or adulterated with gardenia, Safforce+® is DNA-authenticated and entirely free from contamination — 100% genuine saffron.

Why It Works

Supported by clinical research and produced to pharmaceutical-grade standards, Safforce+® modulates serotonin and GABA activity, helping restore emotional balance, relieve stress, and enhance overall mood stability.

Who It’s For

Adults seeking natural support for mild anxiety, emotional fatigue, and sleep quality — without dependency or rebound effects.

When to Use

Ideal for daily use. Users often report noticeable improvement in mood and emotional resilience within a few weeks.

Where It Fits

Perfect for formulations focused on mood, stress, sleep, and healthy aging, where real, traceable, and clinically validated saffron makes the difference.

Safforce+® — Real Saffron. Real Science. Real Results.

Disclaimer:
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Appearance:

White to off-white-crystalline powder.

Melting range:

Ca. 230ºC

Taste:

Only slightly sweet, no distinct side-or aftertaste.

Assay (USP):

Min 98,0%

Dosage:

Oral

Bioaviability:

High

Loss on drying:

Máx. 2%.

Solubility:

Soluble.

Stability:

Stable under normal processing and storage conditions.

A next-generation saffron extract, clinically shown to improve mood and sleep within 6 weeks.

Safforce+® is derived from Crocus sativus L., a delicate flower cultivated for centuries in Spain’s sun-drenched landscapes. Its vivid red stigmas — known as saffron — are carefully hand-harvested at dawn during a brief autumn season, continuing a heritage passed down through generations. Naturally rich in crocin, picrocrocin, and safranal, saffron has long been valued not only as a culinary treasure but also as a botanical ally for mood, sleep, and women’s health.

As the only saffron extract with certified standardization for safranal (2%) and crocins (3%), Safforce+® delivers consistent, measurable results that enhance overall quality of life — supporting emotional balance, restful sleep, and cognitive performance.

A precious spice with a medicinal legacy

6 Weeks

Improved mood, cognition, and sleep quality.

un-cuenco-de-azafran-seco-y-planta-de-flor-de-azafaran-naturaleza-tradicional-en-blanco-generativo-ai

100% Water-Soluble

Easily integrates into diverse formulations.

manos-de-primer-plano-sosteniendo-una-pipeta

Standardized 2/3% Pure

High-quality, content-verified saffron extract.

angulo-bajo-de-hombre-sonriente-al-aire-libre-junto-la-rueda-del-ferry

Effective in Negative Mood

Up to 50% improvement in mood-related symptoms.

Easy Dosage Small
clinically relevant daily quantity

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Standardized for science. Inspired by nature

Safforce+® is more than saffron — it’s a clinically standardized extract with guaranteed concentrations of key bioactives: safranal and crocins. Formulated at doses aligned with international guidelines, Safforce+® provides reliable, evidence-based support for emotional balance, cognitive performance, restful sleep, and metabolic wellness — all sourced from one of nature’s most extraordinary flowers.

Potent actives from a fully traceable source

At Advenion, we partner exclusively with select Spanish growers to obtain the highest-grade saffron — cultivated without genetic modification or harmful inputs. The delicate stigmas are swiftly transported to our nearby facilities, where extraction, standardization, and quality testing take place under direct supervision. This short, transparent supply chain ensures consistent potency and purity in every batch.

Mechanism of action

Balances key neurotransmitters to improve mood and emotional stability.
Enhances circadian rhythm and sleep quality.
Lowers anxiety and supports mental relaxation.
Boosts BDNF and neuronal plasticity for cognitive resilience.

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SLEEP QUALITY & RELAXATION

STRESS REDUCTION

NEUROPROTECTION

EMOTIONAL WELL-BEING

Features & Benefits

Clinically Driven Benefits

• Promotes mood balance and emotional well-being.
• Supports relaxation and sleep quality.
• Clinically validated and standardized for active compounds.
• Proven efficacy and safety in human studies.
• Naturally derived and well-tolerated for long-term use.

Formulation Advantages

• Standardized to 2% safranal and 3% crocins.
• DNA-verified, 100% pure saffron — no adulterants or Gardenia.
• Water-soluble and easy to formulate in capsules, gummies, or beverages.
• Neutral flavor and stable in processing.
• Suitable for natural, clean-label, and premium formulations.

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Ingredients Excellence

Vegetarian

Vegan

Pesticide free

Non GMO

No solvents

No added sugars

Made in EU

Low GI

Gluten free

Proven Health Impact

Source directly from farmers

Skin Tanning Effect

Satiating Effect

Reduced PCOS

Patent

Mood Support

Mental Illness Help

Liver Health

Increses Fertility

Improves Vision

Blood Glucose Control

Trusted Certifications

Kosher

ISO 9001

ISO 22000

ISO 14001

Halal

GMP

FDA

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Propietary Research

Science-backed saffron for emotional balance

Preclinical findings
Safforce+® has shown benefits in models of aging by improving anxiety, memory, and weight regulation through a novel mechanism involving Neuropeptide Y (NPY) — a key modulator of feeding behavior, mood, and cognition.

Mood & Emotional Balance:
Safforce+® supports the natural modulation of serotonin and GABA pathways, helping regulate mood, ease anxiety, and promote emotional stability.

Restful Sleep:
clinically shown to enhance sleep quality, increase restfulness, and support memory and cognitive performance associated with healthy aging.

Pharma-Grade Quality:
Safforce+® is standardized to 2% safranal and 3% crocins, ensuring consistent potency and full traceability.

CLINICAL RESEARCH HIGHLIGHTS:

Depression:

Saffron intake was associated with noticeable reductions in persistent low mood and emotional flatness across several studies involving both clinical and subclinical depressive symptoms.

Anxiety:

Supplementation with saffron appeared to ease subjective anxiety sensations, particularly in response to psychosocial stressors, and was accompanied by reduced cortisol peaks.

Sleep Quality:

Participants reported enhanced ease of falling asleep and better nighttime restfulness following saffron supplementation, especially when baseline sleep issues were more severe.

Cognition:

In individuals with mild cognitive impairment or dementia, saffron was linked to improvements in attention, memory, and overall cognitive performance, with slowed symptom progression.

No data was found

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Market Opportunities

Stress & mood

Safforce+® promotes calm focus and emotional resilience by modulating serotonin and GABA activity, helping reduce daily stress and improve mood stability.

Women’s health

Safforce+® supports emotional well-being and hormonal balance naturally — promoting mood stability and resilience across every life stage.

Energy

Safforce+® helps sustain natural energy and mental focus by enhancing neurotransmitter balance and cellular resilience.

Sleep

Safforce+® supports healthy circadian rhythm and promotes deep, restorative sleep — improving sleep onset, duration, and overall nighttime recovery.

Healthy aging longevity

Evidence-based saffron extract supporting cognitive health, emotional vitality, and quality of life throughout aging.

Cognitive and mood support

Safforce+® enhances focus, emotional balance, and cognitive clarity by supporting neurotransmitter activity and protecting against oxidative stress.

Weight management

Safforce+® helps maintain healthy metabolic function by supporting emotional balance, reducing stress-related eating behaviors, and promoting overall energy efficiency.

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Applications

Tablets

Sticks Packs

Soft Gels

RTDS / Shots

Powders

Gummies

Effervescents

Confectionery

Chews

Capsules

Beverages

Bars

Bakery

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Origins

Rooted in tradition, powered by precision

Safforce+® begins its journey in the sun-drenched fields of Spain, where Crocus sativus L. has been cultivated for centuries. This Mediterranean heritage, combined with ideal soil and climate conditions, yields saffron of exceptional quality — naturally rich in crocin and safranal, the bioactive compounds behind its vivid color and scientifically recognized health benefits.

Locally sourced, scientifically crafted

We work hand in hand with trusted Spanish growers, selecting only the finest saffron stigmas at peak bloom. Each batch is authenticated through advanced DNA barcoding to ensure botanical integrity and purity. Extraction, purification, and standardization are carried out in nearby partner laboratories under our direct supervision. This short, transparent supply chain minimizes environmental impact while ensuring consistent quality and potency.

Total traceability, from flower to final extract

At Advenion, we oversee every step of Safforce+®’s production — from field to finished extract. By managing all key processes, we guarantee complete traceability and pharmaceutical-grade standards for purity, potency, and reproducibility. Each active compound, crocins and safranal, is standardized independently to maintain precise ratios and deliver consistent physiological benefits.

Commitment to people and planet

Our approach to saffron is as responsible as it is scientific. By sourcing locally, collaborating with regional partners, and applying proprietary water-based extraction methods, we reduce emissions and eliminate the need for harsh solvents. This commitment to sustainability, integrity, and innovation ensures that Safforce+® supports not only human well-being — but also the environment that makes it possible.

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Disclaimer:
The information presented in this page is intended to provide general information on our premium products, their properties and potential applications. It is based on our present state of knowledge and must not be construed as guaranteeing specific properties or approvals of the products described herein or their suitability for any application described. The user is solely responsible for compliance with the existing approvals in the county of use. It is also the sole responsibility of the user to investigate whether existing patents are infringed by the use of the materials described herein. Adequate quality of our products is guaranteed under our General Conditions of Sales. All statements in this page have not been evaluated by the US Food and Drug Administration or EFSA. This product is not intended to diagnose, treat, cure, or prevent any disease.