This peer-reviewed study published in Nutrients investigates the effects of D-chiro-inositol (DCI) in female animal models of Alzheimer’s disease, addressing the growing recognition of sex-specific mechanisms in neurodegeneration. The research demonstrates that chronic DCI administration improves cognitive performance while restoring brain insulin signaling through activation of the PI3K/Akt pathway.
The study further shows that DCI reduces tau hyperphosphorylation via modulation of the CDK5/p25 axis, alongside reductions in neuroinflammation and oxidative stress. By targeting metabolic dysfunction at the brain level in female models, this work reinforces the concept that impaired insulin signaling is a key driver of cognitive decline in women.
These findings position DCI as a metabolic-hormonal modulator with specific relevance for female cognitive aging, supporting Gyneos® as a gender-specific nutraceutical strategy integrating metabolic health and brain function.