This peer-reviewed study published in Nutrients demonstrates that oral administration of D-Pinitol activates insulin signaling in the hypothalamus through the PI3K/Akt pathway, independently of insulin secretion and insulin receptor activation. Using an in vivo rat model, the research shows that D-Pinitol enhances central insulin sensitivity while reducing circulating insulin levels and maintaining stable glycemia.
The study identifies D-Pinitol as an insulin-sparing metabolic modulator capable of improving brain insulin signaling, activating key metabolic sensors such as mTOR and AMPK, and influencing pathways associated with energy regulation and neurodegenerative risk. These findings establish a strong mechanistic foundation for Agelity® in metabolic aging, brain insulin resistance, and cognitive health applications.