This peer-reviewed narrative review published in Neural Regeneration Research provides an integrated scientific analysis of the relationship between brain insulin resistance, tau hyperphosphorylation, and neurodegenerative disorders, with a particular focus on Alzheimer’s disease. The article positions D-Pinitol as a key inositol-derived metabolic modulator capable of targeting multiple pathological pathways involved in cognitive decline.
The review highlights how D-Pinitol improves insulin signaling through the PI3K/Akt pathway, regulates CDK5 activity, reduces tau hyperphosphorylation, and exerts antioxidant and neuroprotective effects. By connecting metabolic dysfunction with tau pathology, this publication establishes a strong conceptual and mechanistic foundation for D-Pinitol as a nutraceutical approach addressing brain insulin resistance and neurodegeneration.